井下抽油泵柱塞与泵筒运动规律的研究

用三元振动模型,综合考虑油柱、抽油杆柱和油管柱的振动.建立起数学模型并离散化,然后用微机编程求解微分方程组.对不同工况下的抽油泵运动规律和抽油机示功图进行分析研究,得出了油管应予锚定的结论,并给出了不同抽油机的适用范围.为进一步研究抽油泵的井下工作机理和故障原因打下了基础.     

用正交试验法确定最佳调剖施工参数

针对文明寨油田地质特征和开采现状，按照油藏数值模拟原理，以调剖井对应油井的增油降水创经济效益大小为考核指标，运用正交试验的均衡分散性和整齐可比性及Ｌ９（３４），正交表进行调剖最佳施工参数试验．经现场试验、分析、讨论发现：影响调剖效果的主要因素是措施半径，其次为施工排量和注入方式，且最佳施工参数是措施半径在３．５ｍ左右，施工排量在１９ｍ３／ｈ左右，按连续注入方式调剖。经文明察油田、卫城油田、马寨油田５０井次现场试验证明，较好地改善了注水井吸水剖面，对应油井取得了明显的增油降水效果，收到了较好的经济和社会效益．     

基于FPGA的数字化电力线载波扩频系统的设计

探讨了利用可编程ASIC芯片FPGA实现电力线载波扩频系统的数字调制的新方法 ,介绍了系统的结构、工作原理 ,以及电力线载波扩频系统数字化面临的几个主要问题和解决方法     

ICP-AES光谱仪的研制及其分析软件的设计

目前,市场上的ICP光谱仪仍以国外仪器为主,国内仪器的开发与研制始终未能有所突破,在仪器分析软件上仍属空白,这极大限制了国内ICP光谱仪的发展.本文主要针对单道顺序扫描型ICP-AES光谱仪的硬件及分析软件的开发提供了思路.     

内隐知识的编码

知识的编码是一个渐进的过程，内隐知识和编码知识只是知识在不同编码程度时的表述，其中内隐知识高度依赖行为主体，而编码知识具有可共享性，能够脱离其生产者而存在和传播。内隐知识是伴随性的，它依赖于背景知识和知识生产者的洞察力、直觉、思维模式、信仰、经验等因素。内隐知识主要有四种编码方式：数字化、程序化、定义分类和隐性传播。     

核动力装置模拟器就地系统中双机通讯的实现

利用微机软仿真实现模拟器就地系统中仪表的动态实时显示和开关的实时控制，可以节省的大量外部设备，提高系统可扩充性。本文介绍了该技术实现的方法，即服务器与客户机之间数据双向通讯的实现途径。经实践验证，本文的方法是正确、可行的。     

变频调速装置在离心机拖动系统上的应用

对离心机拖动系统进行变频改造 ,既节约大量电能和设备维修费用 ,提高安全生产可靠性 ,又能提高生产自动化水平     

Science Letters： A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen

It has been proposed that activation of Toll-like receptors （TLRs） plays crucial roles in the polarization of adaptive immune responses. A synthetic Toll-like receptor 2 （TLR2） ligand, Pam3CSK4, has been reported to modulate the balance of Th1/Th2 responses. We evaluated the modulation effect of Pam3CSK4 on allergic immune response in a mouse rhinitis model sensitized to house dust mite allergen （HDM）. Mice were sensitized and challenged with Dermatophagoidesfarinae allergen （Der f）, and then the allergic mice were treated by Pam3CSK4. Nasal allergic symptoms and eosinophils were scored. Der f-specific cytokine responses were examined in the splenocytes and bronchoalveolar lavage fluid （BALF）. Serum level of total IgE was also detected. After establishing a mouse allergic rhinitis model with HDM, we have showed that Pam3CSK4 treatment not only ameliorated the nasal allergic symptoms remarkably but also decreased the eosinophils and total inflammation cells in BALF significantly. Analysis of cytokine profile found that IFN-7 released from either BALF or stimulated splenocytes increased markedly in Pam3CSK4-treated mice, while IL-13 decreased significantly. Moreover, serum level of total IgE was significantly lower in Pam3CSK4-treated mice than in the untreated. Thus, in an allergic rhinitis mouse model developed with HDM, Pam3CSK4 was shown to exhibit an antiallergic effect, indicating its potential application in allergic diseases.     

激光光束质量的评价方法

激光光束质量是一个很有现实意义的论题，对不同应用的激光光束其质量的评价标准一般不同。给出了几种有代表性的激光光束质量的评价方法，并分别对各种评价标准的合理性与适用性进行了详细的分析；研究了实际应用中对激光光束质量的一些要求和相关的评价参数。     

Specific anti-tumor effect induced by attenuated Salmonella typhimurium vaccine expressing extracellular region of vascular endothelial growth factor receptor 2

The purposes of this research were to study the stable expression of exogenous gene encoding therapeutic protein in attenuated Salmonella typhimurium, observe the metabolism of oral gene vaccine carried by attenuated Salmonella typhimurium in BALB/c mouse, and investigate the feasibility of prevention and treatment of tumors by the recombinant bacteria. Recombinant plasmid pcDNA3.1 VEGFR2(n1-7) was transformed into competent attenuated Salmonella typhimurium SL3261 to develop oral DNA vaccine SL3261-pcDNA3.1 VEGFR2(n1-7). To observe whether the exogenous gene can be expressed in the recombinant bacteria, PCR was performed to amplify the CMV promoter of the eukaryotic expression vector as the proof of stable expression of exogenous protein; transmission elec- tron microscopy (TEM) was applied to observe the morphology of the recombinant bacteria to confirm that the exogenous gene has no impact on the growth of the bacteria, and then BALB/c mice were immunized with the gene vaccine. After inoculation of the gene vaccine, the recombinant bacteria SL3261 could be detected in the tissues such as small intestine, colon, liver and spleen. And then, mice in each group were challenged with tumor cells. The results of animal experiment showed that tumor growth of the mice in experimental group was inhibited and survival time of immunized mice was prolonged compared with control groups. A higher lymphocyte infiltration in tumors from animals treated with DNA vaccine was observed. Immunohistochemical analysis of tumor samples revealed an en- hanced accumulation of CD8 cytotoxic T lymphocytes, as well as an increase in CD4 cells in the tumors of animals treated with the oral gene vaccine compared to tumors from control group mice. Ultrastructure of the tumor tissue showed that tumor cells in the samples of the immunized mice were well-differentiated. Our research confirmed that the exogenous gene can be stably expressed in the attenuated Salmonella typhimurium and has no impact on the growth of the recombinant bacteria; the exogenous gene can de delivered to the host by attenuated Salmonella typhimurium to produce anti-tumor effect with no obvious cytotoxity to the host. In this study, it is established that attenuated Salmonella typhimurium could be used as a vector for oral gene vaccine, and our study provided a theoretical basis for the body distribution and the metabolism of the recombinant bacteria. This strategy may provide a simple, safe and effective way for the prevention and treatment of tumors.